The provincial Department of Transportation says part of the 125 Sydney Bypass will be closed for short periods, starting overnight, tonight.
It adds the closures will take place between the George Street Exit and Grand Lake Road, between 11:00 tonight and 5:00 tomorrow morning.
They go on to say the closures will last for about 20 minutes.
The shutdowns are needed to allow for the installation of girders on the new overpass being built over the highway at Cowbay Road.
The closures will take place tonight and tomorrow night and drivers are being encouraged to take another route.